The Effect of Intrathecal Bupivacaine Plus Sufentanil on Intraoperative Hemodynamics During Elective Coronary Artery Bypass Surgery

Introduction: Intrathecal opioids have been used for many patients undergoing surgical operations to improve clinical outcomes. Cardiopulmonary bypass in patients undergoing coronary artery bypass graft surgery carries a number of drawbacks, namely hemodynamic derangements. Several methods have been used to suppress this state; among them is sympathetic blockade by neuraxial anesthesia. This study assesses the effect of intrathecal adjuvant bupivacaine plus sufentanil on intraoperative hemodynamic changes in elective coronary artery bypass surgery. Methods: In a double-blind, randomized, placebo-controlled clinical trials, 80 patients scheduled for elective CABG were randomly assigned into 2 groups. One group received intrathecal sufentanil (S) and the other group received the same dose of sufentanil plus supplemental bupivacaine (SB). All the patients were similar regarding other items. Hemodynamic and clinical outcomes including blood pressure values were measured during and after the operation. Results: There were more stable hemodynamic parameters in the SB group. Also, the SB group patients were extubated sooner than the other patient group. Discussion: The administration of intrathecal sufentanil plus bupivacaine seems to keep the hemodynamic status of the patients more stable than intrathecal sufentanil alone. an anesthesiologist who obtained informed consent, and information regarding the study was given to them. Inclusion criteria were elective CABG cases with informed written consent aged 30-75 years and a weight range of 50 to 100 Kg. Those cases who refused to enter the study, had a history of diabetes mellitus, had any underlying coagulation system disease (esp. those with any coexisting bleeding disorders or a history of platelet dysfunction or low platelet number), or had any sign or history denoting past or present spinal diseases, especially those who needed surgeries for it were excluded from the study. After matching the inclusion and exclusion criteria, induction of general anesthesia was done, then one group received intrathecal sufentanil (S) and the other group received the same dose of sufentanil plus supplemental bupivacaine (SB). Except for this, all the cases were similar regarding anesthesia and surgery. Arterial blood pressures were measured before and after induction of anesthesia, during the bypass time and after weaning from bypass were checked. One of our colleagues anesthetized the cases inside the operating Citation: Dabbagh A, Rajaei S, Taghizade H (2011) The Effect of Intrathecal Bupivacaine Plus Sufentanil on Intraoperative Hemodynamics During Elective Coronary Artery Bypass Surgery. J Anesthe Clinic Res 2:139. doi:10.4172/2155-6148.1000139